While there are no Top-10 matchups on the Week 11 agenda, this week’s college football odds should focus on two notable SEC matchups: Georgia-Mississippi and Alabama-LSU.

I give my picks for those games and for all the other top teams in my best Week 11. college football teams below.

College Football Week 11 Picks Against the Spread

Lines courtesy of DraftKings starting 11-6.

CFB Week 11 ATS Picks

Purdue vs. Ohio State (-38): Purdue +38

Whether it’s disappointment or just worrying about covering a number as gigantic as this, my instinct is to take the points. Not even a score of 42-7 will be enough to achieve the goal.

Miami (-10.5) vs. Georgia Tech: Miami -10.5

Miami has been struggling for much of the season, but I see this as a place to find separation and never look back.

Florida vs. Texas (-21.5): Florida +21.5

Given the quarterback uncertainties, Florida was up seven at the half at Georgia last week and was tied 20-20 in the fourth quarter. Give me the hook for this three-touchdown spread.

Georgia (-2.5) vs. Mississippi: Mississippi +2.5

A win over No. 1 Texas and No. 2-ranked team aside, something doesn’t smell right about this Georgia team. This may be the perfect opportunity for that thought to come to life.

Michigan vs. Indiana (-14.5): Indiana -14.5

It’s a pleasure for this Buckeyes fan to watch Michigan’s season go up in flames, and that won’t change against an undefeated Indiana program that won its six Big Ten games by an average of 26.7 points.

Colorado (-3.5) vs. Texas Tech: Colorado -3.5

Texas Tech did well to end Iowa State’s undefeated campaign, but Colorado is playing as well as anyone could have imagined at this point.

Maryland vs. Oregon (-25): Oregon -25

Oregon is playing at a level that no other team in the country can match. Put the number.

Alabama (-2.5) vs. LSU: LSU +2.5

Alabama continues to look vulnerable in SEC play and finds itself in one of the toughest places in the country to play on Saturday night. I’ll take the points.

Washington vs. Penn State (-13.5): Penn State

To eliminate any doubt about the playoffs, Penn State has no choice but to leave the fight in the rest of its schedule, making this an easy pick with the number of less than two touchdowns.